Dr Louise Newson: [00:00:00] So Davey, it's great to finally meet you. It's always, I find, really interesting and frustrating actually when men talk about hormones it gets so much more attention in social media than when us women talk about hormones and I'm not undermining your intelligence or your knowledge but it's just a bit triggering but I'm using that to my advantage because you've come onto the podcast to talk about hormones as a man, so thanks very much.  [00:00:30][30.0]
‍

Davey Maher: [00:00:31] You're very welcome, Louise. I'm really, I'm excited to be here. And it's true when one thinks of menopause, it's all about maybe hot flashes or night sweats, but it's nobody knows about the impact it has on brain health, bone health, heart health.  [00:00:45][13.8]
‍

Dr Louise Newson: [00:00:46] Yes, absolutely. And I think, as many people know, I'm unusual in many ways, but one way that I'm unusual is that I am a physician, so I am not a gynaecologist, and I'm also a scientist. I've got a pathology degree and I am very evidence-based, but I also really like looking at basic physiology, how hormones work in our body. And once you understand that, everything else is very easy to unpick. But we've got ourselves in a bit of a mess over, I would say the last 80 years since we discovered hormones, because as soon as they were commercialised and prescribed to people, they were prescribed as different products. So I want to unpick that in a bit. But before we do that, just tell me a bit about you and your work and what you do if that's okay.  [00:01:33][47.0]
‍

Davey Maher: [00:01:34] Yeah, for sure. It all started 15 years ago when I started as a personal trainer back in Ireland. My first three clients were women in her 40s, 50s and 60s. I was just basically teaching them very basic body weight exercises in the gym because they were so used to doing excessive cardio. They didn't know anything about strength training. So I was teaching them compound lifts, strength training lifts. And then I started my personal training business in Toronto, Canada.  [00:02:04][30.1]
‍

Dr Louise Newson: [00:02:05] Oh, wow.  [00:02:05][0.2]
‍

Davey Maher: [00:02:06] Nearly 14 years ago. So the majority of my clients were always that demographic, that over 40 woman. And then I was, I started my online coaching in 2016, where I just started getting these crazy results online with women over 40, just when I dialled into their food, their nutrition, like the calorie deficit, the reverse dieting and the maintenance phases. But actually I stopped personal training six years ago, I'm lucky enough, I'm grateful enough to have built out a team now, a coaching team, a marketing team, a sales team and a medical team as well for our clients in the United States. It's not as simple as eat less, move more for the over 40 woman.  [00:02:50][44.7]
‍

Dr Louise Newson: [00:02:52] Yes, and that is so important because for many years, that's the message that we're given and I know myself when I was 45 and I started to get a tummy and I was putting the seatbelt on in the car and just thinking where's this come from? Like I haven't changed anything. I haven't changed my exercise. I haven't changed my nutrition. I don't want to be overweight. Like I've spent my whole life not being overweight. Do you know what I mean? It's not until it happens to yourself that you think, wow, actually, what is going on metabolically in my body?  [00:03:23][31.1]
‍

Davey Maher: [00:03:24] Yeah, look, us men can lose 10 pounds in a week, but women, it's a different ball game. What worked for that demographic in their 20s and 30s does not work in midlife. It takes a different approach. Like when estradiol specifically loses, like starts diminishing, it has a massive effect on a woman's body composition. Just by having bottomed out testosterone and estradiol in a woman body equals more belly fat, less muscle, we don't want that. Sarcopenia sets in, osteopenia. So you've got to work with your body at this phase of life, not against it. So you have to optimise hormones.  [00:04:00][36.5]
‍

Dr Louise Newson: [00:04:02] And that's absolutely true and it's very important because estradiol, like you said, is a specific type of estrogen and I'm very pedantic about language. I've been a medical writer for many years and I feel that I have a responsibility as a medical writer to make sure I explain everything that I say. And I remember years ago writing actually about breast cancer and realised that a lot of people didn't even know what cancer was. So just really unpicking, you know, terms that we use a lot when you're used to them. So estradiol is one type of estrogen, isn't it?  [00:04:37][34.7]
‍

Davey Maher: [00:04:38] Yeah, not many people know this, but there's actually three different types of estrogen. So you have E1, which is estrone. You have E2 which is estradiol, E3 which is estriol. So E2 is very anti-inflammatory. I like to call it the body's armour. It's very protective of a woman's brain, her bones and her heart. Our team prescribe transdermal estradiol for our clients. They are over 40 women in the US. So transdermal means it bypasses the liver. There's no risk of stroke or blood clots. So it's a patch, a cream or a gel. E3, not many people know, estriol is basically, I like to call it the gentle protector. It's very, very powerful for bladder health, for urinary health, or for the vagina. A lot of our clients actually use E3 on their faces, believe it or It's anti-ageing. It increases the collagen. It's used vaginally as well for protection of UTIs, genitourinary syndrome. It can be combined, E2 and E3 can be combined together. So then we have the E1, which is what I like to call the problem child, estrone. It's actually inflammatory. It is more prevalent in women in postmenopausal. So it's very proliferative, meaning it tends to grow things like breast tissue, uterine tissue, fibroids. You don't want that. You don't want that high. It's all about estrogen, how estrogen is metabolised in the liver.  [00:06:25][106.5]
‍

Dr Louise Newson: [00:06:26] Yes, and it's very interesting because estrone is actually also made from our fat cells, our adipocytes as well, isn't it. So one of the ways our body tries to help really, if we don't have enough estrogen, so including estradiol in our body, is it will make more fat cells to try and produce some estrogen, but it gets a bit confused and produces estrone rather than estradiol. And then as you say, estrone, is inflammatory. So when we talk about the so-called harms of estrogen, we need to be really, really precise with our language and talk about, the harms of estrone, as opposed to estradiol. Because as a woman, I want more estradiol in my body and I don't want estrone. And that's really important to understand because metabolically, they're completely different in our bodies.  [00:07:16][49.6]
‍

Davey Maher: [00:07:17] Yeah, it comes down to like synthetic hormones and bioidentical hormones. So synthetic hormones are basically hormones our body does not recognise. They're foreign, they're imposters. So these type of hormones are found in hormonal birth control, like the Mirena IUD, like the Yas, the Yasmin, they are estrogen based birth controls. But they're also found in old school HRT, like Premarin, which is it's an estrogen type of HRT. It's taken from pregnant urine of horses. We are humans! [00:07:49][31.7]
‍

Dr Louise Newson: [00:07:53] Yes, I know. Precisely. So even though people say I want something natural for my menopause, you could argue that pregnant horse's urine is natural, but it's not natural in the human body. So, but you're right. But it's just the estrogen. So like the Mirena coil has a synthetic progestogen in. And again, that language is really important because when we talk about progesterone, that's just one type. It's progesterone that we make as women and we can prescribe it as well, whereas all the other hormones or progestogens that are in the coils, that are in contraception, some older types of HRT. They contain synthetic progestogens, don't they? [00:08:29][36.8]
‍

Davey Maher: [00:08:30] Yeah, just a lot of people get mixed up between progestin and natural progesterone. The two are completely different.  [00:08:39][9.1]
‍

Dr Louise Newson: [00:08:40] It's completely different. And this is really crucial. And I was listening to you talk about it on social media and I really feel that we can't say it enough. And I actually feel quite embarrassed as a doctor that I didn't know the difference for many years. So when I was taking the contraceptive pill many years ago, I was taking ethanolestradiol, which is a synthetic form of estrogen. It's confusing because it's got estradiol in the word but it's also got ethanol. So it's got an ethanol group added to it. So it is not the same as pure estradiol. And then it was also a synthetic progestogen as well. And so they're completely different to my own hormones but my concern when I think about how they work is two-fold really. Firstly, they work differently in the body so they can increase inflammation. But they also block my own hormones working as well, don't they? [00:09:35][54.3]
‍

Davey Maher: [00:09:36] Yeah, I mean, birth control is handed out at a very young age to a lot of young women. Handed out like candy, but they're unaware of what it actually does. It stop the communication between the brain and the ovaries. It shuts it down so not only does it affect the ovaries, it affects the brain. You see it in, depression rises, like there's a higher risk of blood clots. We've seen it in blood work actually with red blood cells, like elevation in some of our clients, we're seeing it now in women in their 40s coming into our programme, been on birth control for years on end. They have thyroid issues like thyropause, I like to call it. They had CRP, which is an inflammatory marker on blood markers through the roof. It's autoimmune diseases. Why is it that 80% of autoimmune diseases are in women? It's because, this is just my opinion, it's because of toxins in the environment, it is because of hormonal birth control. Women are not educated. So they need to be aware of what's going on.  [00:10:38][61.8]
‍

Dr Louise Newson: [00:10:38] Yeah and it needs to be spoken about more and more and I do talk about it but I think sometimes you have to keep repeating it for people to understand and you know a lot of my work is about enabling people to have a choice by giving them the information that's right for them. So if I was 20 years younger, like I'm 55 years old now so clearly I don't need contraception, but if I were 35 and I wanted contraception I could pretty much guarantee to you that I could go to any doctor and get birth control. It would be very easy to get synthetic hormones. If I was 35 and I was experiencing some muscle and joint pain, some fatigue, some low mood, some urinary tract symptoms, dry eyes, whatever, and I thought, oh my periods have become a bit irregular, maybe I'm perimenopausal, and I went to my doctor and said, oh I'd just like to try some estradiol, progesterone, testosterone as HRT because I think I'm perimenopausal. I can pretty much guarantee to you that the majority of doctors would turn me away and say, no, you're too young to be perimenopausal. But which of those is safer? You know, the synthetic contraception or natural hormones? [00:11:49][71.3]
‍

Davey Maher: [00:11:51] Well, first of all, first all, there's a lot of incredible doctors out there creating awareness like yourself and Dr mary Claire and Dr. Vonda Wright and Kelly Casperson. But the fact is, doctors just get 2-4 hours of menopause training in med school, OBGYNs just get 6 hours of menopause training in their four years. So I think the tide is turning though, for sure. There is more.  [00:12:17][26.8]
‍

Dr Louise Newson: [00:12:18] Yeah, and it has to, you know, I realise it's difficult for doctors and nurses and pharmacists and healthcare professionals and I didn't have any formal training, but actually we have a responsibility for our patients and we have a responsibility to do the best for them and we should be kept up to date. It's up to us to be able to be educated on something that affects half the population. You know, we're not talking about something that's really obscure that I might or might not see. You know I might not see a fractured ankle and I don't really need to know the different ways to put a plaster cast on because it's not going to help me as a doctor unless I was an orthopaedic surgeon or working in casualty. But actually if I'm seeing women of any age, surely every single healthcare professional should know something about hormones.  [00:13:07][49.0]
‍

Davey Maher: [00:13:08] Exactly. Like when when we lose our eyesight, we replace them with glasses. When we break our hip, we replace with a hip replacement. When we lose your sex hormones, I mean, it's just a whole taboo. Like bioidentical hormones are, studies have shown when done correctly, they reduced the number one killer in the world for women by heart disease, by up to 50%, they reduce Alzheimer's dementia by up to 33%, they reduce osteoporosis, osteopenia by up to 50%, this is life saving, it's life saving. It's longevity. It's it optimal health. But people aren't aware of of like how powerful, how beneficial these bioidentical hormones are.  [00:13:54][45.4]
‍

Dr Louise Newson: [00:13:55] Well, we've been sold lies for far too long, and this is the problem not just as women, but also as healthcare professionals. We've been given misinformation, and actually we're recording this in the week that the FDA have announced they're removing the black box warning for estrogen products, which is an amazing start, actually, because it's admitting that millions of women have been harmed by not being prescribed hormones. Which I think is a really pivotal time in the history of the health of women.  [00:14:26][31.7]
‍

Davey Maher: [00:14:27] That was a huge announcement during the week because we lost a whole generation of women over the last twenty years by an incorrect WHI study, which was debunked. Like, you know, basically overnight in America 20 years ago, prescriptions of HRT went from 25% of women, over 40 to 4%.  [00:14:49][21.4]
‍

Dr Louise Newson: [00:14:50] It was more, it was from 40%. It was 40% in the US and 30% over here. And I mean, HRT used to be the number one selling pharmaceutical drug. And, you know, but even then that was a synthetic, that was usually Premarin, which was. But even so, it still had hormones in it when we knew there were health benefits and people felt better as well. So we've been trying to, a lot of us, trying to just state the obvious over the last decade or so and met with a lot of resistance actually and even now we're day five after that announcement and there's nothing, nothing in the UK media about this announcement. Whereas if the FDA had put out a statement on Monday to say we found another risk of HRT it would be all across our media and I feel this is really damaging for women because women in the UK are the same as women in the US. You know, there's no difference to our hormones, are there? [00:15:49][59.2]
‍

Davey Maher: [00:15:50] Yeah, and we hear it every day, I mean, for the last seven years, we do like one hour consultations for women wanting to join our programme and what I've learned personally, and I've done 7,000 of these one hour consultations with women on the phone and Zoom. Women are suffering, they're going to their doctors, they are not getting comprehensive testing done, they've been put on synthetic hormones, they have been told get on with it, it's part of ageing, it's just, they are being medically gaslit. They're not getting any support and only 5% of government funding in the US apparently goes towards women's health. It's crazy.  [00:16:28][38.4]
‍

Dr Louise Newson: [00:16:29] It is a scandal because women are living longer, and we want to stay healthy as long as possible. And it's always hard, you know, I spend far too long at my desk and I tend to exercise in the morning because it's done, but I still feel I should be going for walks, I should doing more, and I've got so much else going on. And it is always difficult. But if I didn't have my hormones, I would have muscle and joint pains. And I was getting a lot of migraine as well when my testosterone level was low. And a lot of reduced energy and apathy. So there's no way I would get up earlier in the morning to do a it workout because I would have felt awful. So I know myself personally, I would be feeling very different and my relationship with exercise would be completely different without hormones.  [00:17:16][46.8]
‍

Davey Maher: [00:17:18] Yeah, you mentioned there about your brain health. Like a lot of women have brain fog and low energy. It's not just the ovaries. It actually affects the brain. There's a really interesting book you probably read it, The Menopause Brain by Lisa Mosconi. She talks about images of a woman's brain in her 30s and the same woman, the images of her brain in 50s. The brain shrinks. Actually, there's 30% less energy. Like it affects the dopamine, the serotonin. What do most doctors do? Maybe put them on SSRIs or antidepressants. It's not getting to the root cause.  [00:17:52][33.4]
‍

Dr Louise Newson: [00:17:52] No, and there's also some interesting scans that, if you delve into the literature of women before and after being given the contraceptive pill as well, and how their serotonin levels reduce when they're on contraception. And we see this a lot. I've recorded a podcast with Sophie, my middle daughter, talking about some of her friends that have been put on birth control, and then their mood flattens. And then they're given antidepressants and then they're put on weight and then they're not exercising and a lot of it stems back from them having the contraception.  [00:18:26][34.1]
‍

Davey Maher: [00:18:28] Yeah, I mean, it's not uncommon for new clients to join our programme. Women in their late 40s, 50s and still on the Mirena IUD or for birth control from their OBGYN, claiming that it's going to handle or help with menopause symptoms.  [00:18:43][15.5]
‍

Dr Louise Newson: [00:18:45] And how can it? How can it replace estradiol and testosterone and even progesterone.  [00:18:49][4.1]
‍

Davey Maher: [00:18:51] Exactly. We actually done some testing, recent blood work with a 49-year-old woman who was on the Mirena IUD and her blood work showed some, like her macros, her thyroid, her TSH was very high, free T3, thyroid hormone was very low. She had an autoimmune disease, thyroiditis, Hashimoto's. C-reactive protein, inflammation was high, insulin resistance. All sex hormones were bottomed out. Estrone, the problem child, was actually raised. Okay, so we transitioned her to bioidentical hormone replacement therapy. Within six months, the brain fog left, like she was feeling better, sleeping better, weight loss, she was in a better place to lose body fat. But all her markers, blood markers improved. CRP, inflammatory marker went down, insulin resistance no longer there. Estrone the bad estrogen basically flattened out, estradiol was optimal, testosterone optimal, lipid marker is optimal. That's just the proof, the difference between synthetic hormones and bioidenticals.  [00:19:59][68.6]
‍

Dr Louise Newson: [00:20:01] Yeah, and we see it a lot as well, especially cholesterol coming down, like you say, blood pressure coming down, weight coming down as well and the ability to exercise to improve. So you mentioned earlier about this sarcopenia, this loss of muscle mass, which is really important because you know our muscles obviously hold us up, they hold our skeleton up, but they're biologically and metabolically active as well. They produce lots of hormones into our bloodstream to help keep us healthy, don't they?  [00:20:31][29.5]
‍

Davey Maher: [00:20:31] Yes, women lose up to 3-8% of their muscle mass after the age of 40 every decade. So sarcopenia is a very real thing. Like the more muscle someone has, it prevents insulin resistance. It's going to help with burning more calories. It's gonna give you a healthy metabolism. But I think the mistake that we're seeing over the last seven years that women are approaching their gym, their training with a 'I need to burn calories and lose weight' mindset instead of 'I need to get strong and build muscle' mindset.  [00:21:07][35.2]
‍

Dr Louise Newson: [00:21:09] It is changing, but people are still, I think, sometimes doing the wrong exercise for them as well and thinking, there's a lot more talk about doing free weights, but people are still confused, like, what do I do, how much do I lift and how do I do it, but I think it's so important to have exercise that is right for that individual because I've seen people who think they're really fit and they go running a lot and then they never do any pelvic floor exercises. They're not looking at their core strength and it sort of catches up with them a bit and they become in their 40s or 50s.  [00:21:46][36.7]
‍

Davey Maher: [00:21:47] Yeah, I think a lot of that demographic are going to the gym but doing too higher reps Lifting the light pink dumbbells and afraid to lift heavy weights, which is more endurance. Like we've got to train for strength to grow muscle in the five to eight rep range.  [00:22:06][19.8]
‍

Dr Louise Newson: [00:22:08] It's really important, I was doing some weights this morning actually, and my husband does weights and his are ridiculously big, I can't even lift them when I'm trying to like just clean up. But it's interesting because over the last few months, I've actually got more weights out of his room into my room, because I can hold stronger, bigger weights and actually something I was doing this morning I did a few weeks ago, I found really hard and I found it so easy that I needed to get a heavier weight. So I was like, oh, that's progress. That's amazing. So it's quite impressive actually.  [00:22:40][31.9]
‍

Davey Maher: [00:22:41] That's fantastic. Cardio is important too.  [00:22:45][3.7]
‍

Dr Louise Newson: [00:22:46] It totally, yeah.  [00:22:47][1.0]
‍

Davey Maher: [00:22:49] But I think that that age group, that demographic are doing excessive amounts of cardio, like the midlife woman is already stressed with a high performing job, they're looking after their kids, their elderly parents, they are doing these boot camps in the morning, adding more stress. So it's more low intensity, moderate cardio is more beneficial.  [00:23:12][22.9]
‍

Dr Louise Newson: [00:23:14] Yeah, absolutely. It's so important. And I think, unless people understand different types of exercise, you know, as a doctor, we're taught to just ask people, do you exercise? Yes or no? How long do you do exercise for? But I think you learn a lot more from people when you hear about the types of exercise that they do. But one of the things that frustrates and saddens me is that a lot of women are told, well, you are menopausal now you don't need to do as much exercise or you might want to modify your exercise  or you're perimenopausal, you might have some days where you feel worse, so just sit it out and don't exercise. And there's quite a few, I'm sure you've seen them as well, personal trainers who are 'experienced', I say in inverted commas, in menopause, so they can guide you through a modified programme. And I feel like stronger than I have done for many years, but I'm clearly menopausal, but I take hormones and I feel very strongly that if women want to take hormones, they should be able to exercise the same every day. We shouldn't have to duck and dive because our own hormones are lowering and just sit it out.  [00:24:22][68.3]
‍

Davey Maher: [00:24:25] Yeah, it's a different approach is needed for everything in midlife. Not just training, but like nutrition as well. Like under eating. A lot of women in that age group are unintentionally under eating, like they're already losing their bone, their muscles. So one meal a day doesn't cut it. How can you hit your protein and fibre goals eating 1,200 calories a day? So everything needs to be dialled in, not just training, hormone health. Liver support, like if a person has a sluggish liver, they're not detoxifying the estrogen properly. Hormones will not be optimised. They won't work. Like if you have an inflamed gut, which we see all the time, hormones are basically useless. You need everything working optimally.  [00:25:11][45.8]
‍

Dr Louise Newson: [00:25:12] Yeah. That's where looking at nutrition as well is super important because it's so easy now to eat badly. Recently I was out and I just struggle to find just some fresh fruit and veg from where I was walking through and I'm just like, oh, hang on, this is really difficult and it's hard for people and because I have migraine, if I don't eat healthily, it will trigger migraines. So I can't just eat a protein bar or a snack bar. I have to sit and eat proper food. But I think now people think they can get away with not having such good nutrition and it catches up.  [00:25:50][37.8]
‍

Davey Maher: [00:25:51] We got away with it in our 20s, late nights and crappy food, but we don't get away with it in midlife, that's for sure.  [00:26:00][9.2]
‍

Dr Louise Newson: [00:26:00] Yeah There's so much we need to think about. So I'm really grateful for you coming on and just trying to unpick some of it so people can make decisions that are right for them. So before we end, I always ask for three tips and I'm just keen to ask you three, we've mentioned it already, but three reasons why people should consider doing maybe slightly different exercise when they're menopausal or when they are just older to help with their bones and muscles in particular.  [00:26:30][30.3]
‍

Davey Maher: [00:26:32] Yeah, you got to look at muscle as I think is the greatest anti-ageing product a woman over 40 can have. You have to, whether we like it or not, dial in strength training. So three times a week in that five to eight rep range. You don't have to lift heavy weights like at the start. Just get your form right. Get your technique right first and slowly build up the progressive overload over time. Cardio is very beneficial for the lungs, the brain as well. So try that 80% of your cardio should be that zone to fat burning zone, like 220 minus your age and then get 60-70% of your max heart rate. But there's nothing wrong with high intensity cardio as well, it can be maybe 20% of your cardio come from maybe high intensity type of cardio.  [00:27:28][56.1]
‍

Dr Louise Newson: [00:27:33] Great, go on...  [00:27:33][0.2]
‍

Davey Maher: [00:27:33] I just want to talk about testosterone, just really briefly, Louise, because a lot of people think that it's just a bodybuilding steroid or a man's steroid, but it's actually the most abundant hormone throughout a woman's lifetime. It's produced in the ovaries, the adrenal glands. So, every woman that comes into our programme, none of them have been on testosterone, but it's actually the first hormone that we add in. We microdose it with our clients or the women. So they only need one tenth of it compared to men. So why do we prescribe it? We're seeing great results with our female clients microdosing testosterone for less brain fog, more energy, but it actually builds bone. So it's, I think it's a very important hormone, not just for men, it's for women as well.  [00:28:26][52.9]
‍

Dr Louise Newson: [00:28:27] Totally. Absolutely, and we need to be thinking about it as an important biologically active hormone rather than just something for libido because it has an effect on every single cell in our body, of course.  [00:28:39][11.4]
‍

Davey Maher: [00:28:40] But it's not the magic bullet either, just lastly, but we have a lot of our new clients thinking that BHRT is going to magically help them to burn fat. When we look at what they're eating, they're not eating enough nutrients or food or protein. They're not moving. They're stressed out of their mind, sluggish liver, inflamed gut. If you don't dial in the other aspects, the foundations of health, hormones will not work.  [00:29:06][26.0]
‍

Dr Louise Newson: [00:29:07] Yeah, absolutely. It's so important to look very holistically and certainly we do a lot in our clinic as well but you know, yes, I use hormones, but I can't just sit there and expect them to do everything for me Thank you so much for your time, it's been really good  [00:29:25][17.4]
‍

Davey Maher: [00:29:25] Thanks very much Louise.  [00:29:25][0.0]